BerlinAnalytix investigate a novel bovine based membrane in a 90-day study
The majority of resorbable barrier membranes used in the clinical context of maxillofacial surgery are produced from porcine sources, which may be undesirable to some patients for ethical or religious reasons, depending on their beliefs, prompting them to use non-resorbable membranes as a result. Because of this, a native bovine collagen type I-derived membrane was investigated by the BerlinAnalytix team in comparison to two clinically used native porcine-based barrier membranes (i.e., Jason® and Biogide® membranes). The methods utilized in this publication included biocompatibility scoring in accordance with the DIN EN ISO 10993-6 standard, histomorphometrical analyses of the presence of M1 and M2 macrophages, and vascularization analyses to determine the extent of vascularization. It was discovered that M1 and M2 macrophage polarization were equivalent to those seen in commercially available controls after a 90-day subcutaneous implantation was performed and analyzed. Our histomorphometrical methodologies also allowed us to notice that the unique membrane maintained its thickness for up to 90 days, which was a breakthrough. Finally, the vascularization of the bovine membrane was shown to be larger than that of the control groups. A further finding was that the bovine membrane displayed a distinct vascularization pattern from that of the controls, which led to the coining of the term "transmembraneous vascularization."
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In Vivo Biocompatibility Analysis of a Novel Barrier Membrane Based on Bovine Dermis-Derived Collagen for Guided Bone Regeneration (GBR)
Authors: Lindner C, Alkildani S, Stojanovic S, Najman S, Jung O, Barbeck M.
Membranes (Basel).2022 Mar 30;12(4):378. doi: 10.3390/membranes12040378. PMID: 35448348